09 February 2023
NOVA Healthcare UX – User Experience Research in health
NOVA Healthcare UX designs organizational changes aiming at better healthcare experiences for users, which is key to person-centred care.
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07 July 2021
Crystalsense – electronic nose using novel gas sensing materials
A new sensing solution for a bio-inspired electronic nose, able to “smell” mixtures of volatile organic compounds. (more…)
06 July 2021
Treatment of spinal cord injury
Therapy for spinal cord injury: the elimination of senescent cells improves recovery and healing after spinal cord injury in mammals. (more…)
06 July 2021
System for Selective and Controlled Sampling of Exhaled Air
A system and method for selective sampling of exhaled air in which the user exhales into the portable sampling device and the breath flow is calculated from the user’s air flow temperature obtained by the sensor. Furthermore, it is possible to correlate the air flow with the variation of temperature of the exhaled air. (more…)
06 July 2021
Explosion Energy Dissipation System
The invention allows the flexible use in terms of dimensions, available deformable material and type of material used, maintaining a highly stable behaviour for the dissipater during the process of dissipation, allowing it to adapt its characteristic to any existing structure or any yet in construction so that it absorbs and redistributes the remaining energy of the explosion by the overall structure, protecting the elements that are essential to structural stability. (more…)
06 July 2021
Engineered enzyme-like polymer particles for catalytic processes
This technology describes a new strategy for production of enzyme-like polymer particles useful for industrial catalytic processes. Versatile, very specific and multi-functional template-monomer complexes were synthesized for further use in polymerization reactions where highly stable and reusable polymer particles are obtained with catalytic activity. (more…)
06 July 2021
Innovative process for obtaining multiple Polymer Ionic Liquid (PILs) gels electrolytes from renewable source
The present invention describes an innovative process for obtaining multiple Polymer Ionic Liquid (PILs) gels electrolytes from renewable source. (more…)
06 July 2021
New eddy currents probe for tubular geometries
The invention consists of a new eddy currents probe for non-destructive testing of components with circular geometry. The probe is composed by 2 main features, the sensitive coil and the excitation winding which disposition allows a greater sensibility in the components testing. (more…)
![Novel multi-resistant microbial, biofilm and biofouling hybrid isoprenoid inhibitors isolated from MAR4 strains [NI-TECH-2020-28]](https://novainnovation.unl.pt/wp-content/uploads/2021/07/Actinomyces.jpg)
06 July 2021
Novel multi-resistant microbial, biofilm and biofouling hybrid isoprenoid inhibitors isolated from MAR4 strains
Actinomycetes targeted from marine sediments collected off Madeira Archipelago, located at the unexplored Macaronesia Atlantic ecoregion. (more…)
06 July 2021
Innovative one-pot method for synthesis of a chemical building block in human healthcare, from succinic acid in carbon dioxide and ionic liquid media.
A new method to produce a chemical compound named 9-Thiabicyclo[3.3.1]nonane-2,6-dione in a one-pot process was invented.
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PAST CALLS: 09 August 2021
Innovative Therapies for the Treatment of SkinDisorders
PAST CALLS: 09 August 2021
Selectively Printing Molecules and Generating Images on Curved Polymers
![Removal of micropollutants and microorganisms from aqueous matrices [NI-TECH-2020-26]](https://novainnovation.unl.pt/wp-content/uploads/2021/06/microorganisms.jpg)
25 June 2021
Removal of micropollutants and microorganisms from aqueous matrices
Electrochemical reactor for the removal of micropollutants and microorganisms from aqueous matrices applied in a time window of hours. (more…)
![Block Windowed Burst Orthogonal Frequency Division Multiplexing Transmission Method with Window Overlapping and Time-Interleaving [NI-TECH-2020-25]](https://novainnovation.unl.pt/wp-content/uploads/2021/06/OFDM.jpg)
25 June 2021
Block Windowed Burst Orthogonal Frequency Division Multiplexing Transmission Method with Window Overlapping and Time-Interleaving
Orthogonal Frequency Division Multiplexing (OFDM) is still at 5G (and since 3G) the preferred modulation of choice, due to its robustness to inter-symbol interference associated with multipath channels. (more…)
PAST CALLS: 29 July 2021
Innovative DMPK and Safety Research for Therapeutics and Drug Delivery Systems
PAST CALLS: 29 July 2021
Innovations in Platform Technologies: New Modalities and Drug Delivery Systems
PAST CALLS: 29 July 2021
Novel Targets and Treatments in Oncology and Immunology
PAST CALLS: 29 July 2021
Innovative Therapeutic Targets, Drugs, Disease Mechanisms and Technologies in Neuroscience
PAST CALLS: 19 July 2021
In-Silico, Predictive Formulation Development Tools and Computational Methods
PAST CALLS: 19 July 2021
Controlled Release of Orally Delivered Dosage Forms
11 June 2021
NOVA Asset Administration Shell
Implements the concept of the Digital Twin of a physical object turning it into an Industrie 4.0 component that facilitates interoperability in industrial applications
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11 June 2021
Risk Analysis Applied to Collections
Risk Analysis Applied to Collections is based in the 10 agents of deterioration from Canadian Conservation Institute and the Risk analysis model developed by Robert Waller
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11 June 2021
Measuring Pollutants in Museus or other Institutions with Cultural Heritage
The main pollutants in museums are measured and the results will be analysed in a report.
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11 June 2021
NOVA PSOA – Advisory in implementing and evaluating social prescription
NOVA-PSOA supports institutions in the sectors of health, social or local authorities to implement and evaluate projects of Social Prescribing
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11 June 2021
Microplastics research and analyses
Sampling, detection, characterization and polymer analyses of microplastics in water, sediment, soil and biological matrices
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11 June 2021
UAV Technology and Innovation tools for a Sustainable Management of the Portuguese Coastal Zone
Risk and Civil Protection Assessment and Management using UAV technology
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11 June 2021
Green infrastructures, ecosystems based-management and nature-based solutions. Tools for sustainable land management
Green infrastructures, ecosystems based-management and nature-based solutions. Tools for sustainable land management.
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11 June 2021
Optimization of Industry 4.0 Operations
Optimization of processes and operations in manufacturing and services using emergent and digital technologies
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11 June 2021
Design of Digital and Sustainable Supply Chains
Sustainable supply chain design in the era of digitalization
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11 June 2021
Lean, Agile and Digital Healthcare Systems
Transforming healthcare organizations through lean and agile management thinking and emergent digital technology
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11 June 2021
Nuclear Magnetic Resonance (NMR) analysis
The development of new products depends on the ability to characterize materials. NMR is an analytical technique for the structural analysis of materials at the molecular level and the evaluation of potential applications
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11 June 2021
NOVA ƐrgoLab – studies on ergonomics (physical work and/or user interface development)
Specialized studies on Physical Ergonomics (workplace design) and Human-System interaction (analogic or digital user-centered interfaces)
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11 June 2021
Single-crystal X-ray diffraction for structure solution of small molecules
Single-crystal X-ray diffraction is undoubtedly the most powerful technique for the complete structural elucidation of molecules.
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11 June 2021
Empowerment of Patients’ Associations
Empowerment of Patients' Associations, through their preparation for shared decision-making, in the context of health policies (more…)
11 June 2021
BioLab – Biological and Chemical Analysis Facility
The BioLab gathers in a single unit state-of-the-art biophysical and biological technologies, devoted to the comprehension of cellular and molecular mechanisms
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09 June 2021
PYCC – Portuguese Yeast Culture Collection
Microbial characterization with phenotypic and molecular methods. Microbial genomics. Contract research on microbiology and molecular biology. Maintenance of industrial strains. Provider of more than 5000 certified microbial cultures.
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09 June 2021
METROVAC – Laboratory for vacuum technology and metrology
Metrovac in an ISO17025 accredited laboratory for calibration of vacuum gauges and reference leaks, as well as testing leak detectors
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09 June 2021
Be Glass: Production and Characterization of Glass Samples
Connects present and past technologies for the production of glass that are now available for the community.
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09 June 2021
Metabolomics Data Analysis Service
A CEDOC-NMS research group with extensive experience in basic and clinical research, metabolomics, LC-MS and statistics, offers support in the analysis of metabolomics data.
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09 June 2021
Environmental Burden of Disease Analysis
Burden of disease, with an economical evaluation, related with exposure to environmental contaminants (air pollutants,chemical contaminants)
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09 June 2021
Science to support Policy Action in Chemicals Risk Management
Support agencies at National and European Level concerning exposure and risk assessment to support policy actions that can guarantee and adequate risk management measure
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09 June 2021
Advanced thin-walled beam finite elements
Advanced thin-walled beam finite elements that can be used to model the behaviour of beam-like structures subjected to cross-section deformation
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08 June 2021
Laser System PLS6MW: Cutting and Engraving Machine
The PLS6MW (Multi-Wavelength) is a free-standing platform that uses multiple laser wavelengths to process the broadest possible spectrum of materials and supports either CO2 or fibre lasers.
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08 June 2021
Synthetic antigen biosensor for detection of Pneumocystis pneumonia
A Pneumocystis jirovecii recombinant synthetic antigen and an ELISA for detection of anti-P. jirovecii antibodies, were developed for the serodiagnosis of severe interstitial pneumonia (more…)
08 June 2021
Virtual Museum of Traditional Fisheries
Co-building of a Virtual Museum of Traditional Fisheries to enhance the natural, historical and cultural heritage of the fishing communities. (more…)
08 June 2021
Smart Fishing
The Smart Fishing project was designed to make face to safety and sustainability issues in artisanal fishing through the community-based development of an Integrated Technological Solution. (more…)
14 May 2021
NOVA places knowledge at the service of the city with the new Campolide Campus
The Campolide Campus Day was celebrated today with the presentation of the concept for the new campus. (more…)
14 May 2021
NOVA’s Rector highlights CoLab of Elvas as an ally of sustainability
The Rector of NOVA University Lisbon, João Sàágua, stated that the collaborative laboratory (CoLab) InnovPlantProtect (InPP), is an ally of sustainability in agricultural production, as it has been developing innovative solutions to protect crops from pests and diseases. It was in an interview with Vida Rural magazine that the Rector of NOVA spoke about the importance of this CoLab installed in Elvas, which is coordinated by NOVA. (more…)
19 February 2021
Clinical research unit of NOVA
NOVA-CRU intends to foster the execution of independent clinical studies, in accordance with good clinical practice, promoting the creation of an infrastructure to support researchers in conducting clinical studies, thus contributing to the generation of relevant evidence and impact on clinical practice.
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19 February 2021
Lung function assessment and inflammatory biomarkers of the airways
High quality services in the area of lung function tests and assessment of airways inflammation.
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19 February 2021
NOVAgli – NOVA glycemic index
NOVAgli is a service to determine food or meal glycemic index and glycemic load, according to the impact on postprandial blood glucose, increasing knowledge about their metabolic effect.
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19 February 2021
NOVAcan – NOVA corporate advice in nutrition
NOVAcan provides consultancy in nutrition, metabolism and health promotion. This service may be requested by entities that need assistance and validation of scientific information
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19 February 2021
NOVAcnr – Clinical nutrition and metabolism research
NOVAcnr is a specialized service in nutritional clinical trial. The service includes study design, with or without intervention, ethical documentation support, trial execution, data treatment and analysis and report.
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19 February 2021
NOVAlia – NOVA kitchenlab @LIA
The NOVAlia provides interactive training to participants in nutrition science, cooking techniques and food preparation.
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19 February 2021
PIDLAB – Primary immunodeficiency laboratory
PIDLAB - Aiming for better diagnostic approaches in Primary Immunodeficiency and Immune disorders
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19 February 2021
Tailored people-centric solutions to foster drug development, research, science communication and health literacy
CDG&Allies provides tailored people-centric solutions to foster drug development, research, science communication and health literacy
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19 February 2021
UniMS mass spectrometry unit
Mass Spectrometry (MS) to the scientific community and industry, guaranteed by a continuous increase in MS know-how and infrastructures
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19 February 2021
NMR services for product development and quality control – molecular identity, structure and quantity
NMR spectroscopy is the most versatile analytical technique at our disposal, allowing the detection, quantification and structure determination of most molecules.
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19 February 2021
Audio recording and audio post-production studios
Audio recording, editing and post-production.
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19 February 2021
Chroma key video studio
Video recording (chroma key available), editing and post-production services.
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19 February 2021
Binaural audio recording
Binaural audio recording, editing and post-production
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19 February 2021
Production of digital interactive games
Production of digital interactive games
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19 February 2021
360º Video and 3D audio recording and post-production
360 video recording, editing and post-production services.
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23 September 2020
Professor Elvira Fortunato is the winner of the Horizon Impact Award 2020
Elvira Fortunato, is the winner of the European prize Horizon Impact Award 2020. INVISIBLE, the only Portuguese project among the 10 finalists, was distinguished today during the event “European Research and Innovation Days”.
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![BACKGROUND The congenital malformations, arthritis, osteoporosis, traumatic accidents, spinal deformities, among others are the basis for need bone and cartilage replacements. The chronic pain, inflammation or discomfort of these diseases translates into a significant impact on patients’ and hospital treatments costs. There is yet no solution that meets the structural and functional requirements of definitive implants. In the case of trauma, for example, treatment often consists of bone joining or even implants in a nonpermanent situation, that is, requiring more than one surgical intervention which causes pain and discomfort to the patient besides the costs involved. Therefore, the development of low cost, durable, compatible and functional solutions is needed. Namely bone substitutes that can be perfectly integrated, morphologically and anatomically biocompatible, with complex structure and a material that mimics native bone and encourages cell migration, proliferation and differentiation. Ideally a bone substitute has original three-dimensional anatomical shape the trabecular zone is dense and has Young’s modulus in the range of 0.01-0.5 GPa and compressive strength values of 4-12 MPa while the cortical region is porous with compressive strength values in the range 130-225 MPa and modulus Young from 3-30GPa. The development of bone implants represents an area of medicine attracting growing interest in recent years. Most used implants are made of noble metals such as titanium. This material, although with good biocompatibility, strength and durability characteristics, faces often body rejection problems. To avoid that, the metal is coated with a biocompatible ceramic material (zirconia, hydroxyapatite, etc.). Despite their good performance, titanium implants have a much higher Young’s modulus than bone, which leads to localized stress phenomena, increase of osteoblast activity and may lead to periprosthetic osteolysis and consequent implant failure. The 3D printing techniques provided opportunities for the development of customized pieces. Ceramics, plastics and metals are all possible to printing in three dimensions by additive or subtractive techniques. In particular subtractive techniques are already used to perform ceramic teeth for dentistry. A piece of dense ceramic material is mechanically dug until the desired form is obtained. However, the dense ceramic implant behaves most likely the metal implants as it doesn’t allow the body fluids to flow through it. Compared to other techniques, the great advantage of pastes extrusion technique is the facility to mimic the graded porosity of implants while a specific design according to patient needs, reaching the mechanical properties close to those of the native bone, as well as their adequate, porosity, permeability to cells, biocompatibility and durability. The goal of the NOVA researchers is to develop low cost production ceramic implants, permanent, conformal and compatible with the specific needs of patients, mimicking resistance and bioactivity. This approach was achieved in preliminary results focused in 3D printed pieces of ceramics powders, achieving mechanical properties in the range of cortical bone, the most demanding in terms of mechanical strength. Indeed, the cortical mechanical resistance values were achieved just printing pieces layer-by-layer with pastes made with inorganic and organic compounds. The required biocompatibility and osteointegration was also tested in-vivo. TECHNOLOGY OVERVIEW The obtained background data show a real possibility to implement this technology in the veterinary area special to horses, dogs and cats in a first phase. This will open then possibilities and verification to further human applications. From left to right: Sample draw; printed samples after sintering for compression test; geometry and dimensions to tension tests; samples geometry for flexure tests. The mechanical strength obtained from axial compression, the tension and the flexure tests are summarized in table 1, where the obtained values are compared to the trabecular and cortical bone values obtained from literature. Comparison of mechanical teste with bone (values from literature).[1][2] Density and porosity compared to bone. The in-vitro tests were made with SAOS 2 cellules tinted for alkaline phosphatase with naphthol AS-MX phosphate and fast red violet and images of cell proliferation obtained for day 5 (left image) and 11 day (right image) of culture are shown in Figure 2. Figure 2: Image of SAOS 2 cells on the top a PIC sample for day 5 (left) and day 11 (right). The graph shows the evolution of cells growth along 9 days. The in-vivo tests were performed in rabbit being implanted two different samples S1 and S2 and the radiography images obtained after 2, 4 and 12 weeks are shown in Figure 3. Figure 3: Image of the implant (left). The graph represents the % of the bone-to-implant contact (BIC) evolution for two different composition samples. There was no adverse response, either local or systemic. No clinical symptoms of exaggerated inflammation, edema or infection were identified. No extensive bone resorption of the surrounding bone tissue is identified STAGE OF DEVELOPMENT The Technology Readiness Level (TRL) is 4. BENEFITS The main advantage of this technology is to allow the printing of a customized bone according to the needs of replacement. It enables the production of bone with gradient of density, in the exterior, properties similar to cortical bone, and, in the interior, density and properties of trabecular bone. Adding to that, the good osteointegration of the material, will allow a giant step towards bone’s mimicking especially for implants in animals, as a first step. Avoiding the need for a second operation for removing metallic parts, or due to rejection problems. APPLICATIONS The potential market is the implants in animals, horses, dogs and cats. There is a huge market for pets, which will allow also to consolidate the technology before it can be implemented in humans. OPPORTUNITY The NOVA team is looking for a co-development partner or a licensee for the implementation of this technology. IP STATUS Know-how based SEEKING Development partner Licensing](https://novainnovation.unl.pt/wp-content/uploads/2021/02/tech_image_2.7ccfbcf1.jpg)
28 August 2020
3D printing of bone-like structures for bone replacement in animals
3D printable ceramics compatible with cortical bones which have demonstrated good osseointegration in in vivo tests (more…)
17 July 2020
Start-up of former NOVA student wins Santander Global Contest with smart box to preserve food
Mater Dynamics, a start-up founded by Tiago Cunha Reis, a former student at NOVA, developed the Stamply Box, a smart box to conserve perishable food and protect it from contamination, that was distinguished today as one of the winners of Santander X - Tomorrow Challenge. (more…)
07 July 2020
Green plastic antibodies
Green plastic antibodies developed using a green technology, supercritical carbon dioxide for a wide range of applications (more…)
18 May 2020
Phenylpropanoid saccharide esters, methods and uses thereof
Phenylpropanoid saccharide esters with different degrees and place of substitution, and their use as antimicrobial and cytotoxic agents (more…)
30 March 2020
Menthol-fatty acids eutectic systems as anti-bacterial agents and wound healing enhancers
A composition of menthol: fatty acids, in the appropriate molar ratio to form a deep eutectic system, presenting antibacterial properties. (more…)
17 March 2020
EK reactor – electrodialytic technology as a pre-treatment for wastewater reuse applications
Improved electrodialytic technology for materials and irrigation sector application and hydrogen production for clean energy production (more…)
22 January 2020
Web-based video annotation tool in real-time
A web-based tool to annotate videos involving human motion with multiple annotation track timelines, including text, images and touch-pen. (more…)
22 January 2020
Limonene ibuprofen therapeutic deep eutectic system for Anticancer Therapy
A composition of limonene and ibuprofen, in the appropriate molar ratio to form a deep eutectic system. (more…)
22 January 2020
Zero curvature polyhedric roofing
A single zero curvature polyhedric surface for roofing structure and weather protection. (more…)
22 January 2020
Transmedia knowledge-base for Performing Arts: a dynamic archive for creative processes
A digital and unique open-ended multimodal knowledge-base to document, annotate and support the creation of performing arts. (more…)
22 January 2020
Green syngas from carbon dioxide
A concept of electrodes based on non-noble metals that can produce syngas with a tuneable composition. (more…)
22 January 2020
Dendritic cell-based therapies for cancer treatment
Viable dendritic cells with up to twice as capacity to boost antigen-specific anti-tumour and anti-viral activity (more…)
22 January 2020
Low energy electron interactions with gas-phase molecules for pharmaceutical applications
A trochoidal electron monochromator coupled with an orthogonal reflectron time-of-flight mass spectrometer to monitor LEE interactions. (more…)